tailieunhanh - Báo cáo y học: "Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study. | Karlsson et al. Critical Care 2010 14 R205 http content 14 6 R205 KS CRITICAL CARE RESEARCH Open Access Predictive value of procalcitonin decrease in patients with severe sepsis a prospective observational study 1 2 3 4 2 2 5 6 Sari Karlsson Milja Heikkinen Ville Pettila Seija Alila Sari Vaisanen Kari Pulkki Elina Kolho Esko Ruokonen the Finnsepsis Study Group1 Abstract Introduction This prospective study investigated the predictive value of procalcitonin PCT for survival in 242 adult patients with severe sepsis and septic shock treated in intensive care. Methods PCT was analyzed from blood samples of all patients at baseline and 155 patients 72 hours later. Results The median PCT serum concentration on day 0 was ng ml interquartile range IQR and ng ml and ng ml IQR and ng ml 72 hours later. Hospital mortality was 62 242 . Median PCT concentrations in patients with community-acquired infections were higher than with nosocomial infections P . Blood cultures were positive in of patients n 69 and severe sepsis with positive blood cultures was associated with higher PCT levels than with negative cultures P . Patients with septic shock had higher PCT concentrations than patients without P . PCT concentrations did not differ between hospital survivors and nonsurvivors P and P respectively but mortality was lower in patients whose PCT concentration decreased 50 by 72 hours compared to those with a 50 decrease vs. P . Conclusions PCT concentrations were higher in more severe forms of severe sepsis but a substantial concentration decrease was more important for survival than absolute values. Introduction Because promptly administered antimicrobial and early goal-directed treatment has been shown to improve outcome in patients with severe sepsis 1 2 early recognition of infection as a cause of critical illness is of major importance. Various biomarkers such as C-reactive protein CRP .