tailieunhanh - Báo cáo y học: "A third-generation microsatellite-based linkage map of the honey bee, Apis mellifera, and its comparison with the sequence-based physical map"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A third-generation microsatellite-based linkage map of the honey bee, Apis mellifera, and its comparison with the sequence-based physical map. | Open Access Research A third-generation microsatellite-based linkage map of the honey bee Apis mellifera and its comparison with the sequence-based physical map Michel Solignac Florence Monge Dominique Vautrin Monique Monnerot and Jean-Marie Cornuet Addresses Laboratoire Evolution Génomes et Speciation CNRS 91198 Gif-sur-Yvette cedex France. Université Paris-Sud 91405 Orsay cedex France. Centre de Biologie et de Gestion des Populations Institut National de la Recherche Agronomique CS 30016 Montferrier-sur-Lez F34988 Saint-Gély-du-Fesc France. Correspondence Michel Solignac. Email solignac@ Published 21 May 2007 Genome Biology 2007 8 R66 doi 186 gb-2007-8-4-r66 The electronic version of this article is the complete one and can be found online at http 2007 8 4 R66 Received 6 November 2006 Revised 6 February 2007 Accepted 21 May 2007 2007 Solignac et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The honey bee is a key model for social behavior and this feature led to the selection of the species for genome sequencing. A genetic map is a necessary companion to the sequence. In addition because there was originally no physical map for the honey bee genome project a meiotic map was the only resource for organizing the sequence assembly on the chromosomes. Results We present the genetic meiotic map here and describe the main features that emerged from comparison with the sequence-based physical map. The genetic map of the honey bee is saturated and the chromosomes are oriented from the centromeric to the telomeric regions. The map is based on 2 008 markers and is about 40 Morgans M long resulting in a marker density of one every centiMorgans cM . For the 186 .