tailieunhanh - Báo cáo y học: "Developing a systems-level understanding of gene expression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Developing a systems-level understanding of gene expression. | Meeting report Developing a systems-level understanding of gene expression Olivier Elemento Address Lewis-Sigler Institute for Integrative Genomics Princeton University Princeton NJ 08544 USA. Email elemento@ Published 30 April 2007 Genome Biology 2007 8 304 doi gb-2007-8-4-304 The electronic version of this article is the complete one and can be found online at http 2007 8 4 304 2007 BioMed Central Ltd A report on the meeting Systems Biology Global Regulation of Gene Expression at the Cold Spring Harbor Laboratory New York USA 28 March-1 April 2007. This year s annual systems biology meeting at Cold Spring Harbor showcased a wide range of experimental computational and theoretical approaches to studying the multiple facets of gene expression. The meeting also featured new technologies several large-scale studies and studies on a diversity of model organisms - from Escherichia coli through Arabidopsis to humans. Protein-DNA interactions In his keynote speech Uri Alon Weizmann Institute Rehovot Israel described how complex regulatory networks can be decomposed into simple and recurrent patterns which he terms network motifs. Mathematical analysis predicts the dynamic functions of these motifs and Alon s group has verified several of these predictions using highly accurate measurements of promoter activity in vivo. For example he showed that the Escherichia coli L-arabinose-utilization system uses a motif called a feedforward loop for a delayed response to cyclic AMP stimulation and a rapid response to cAMP depletion. Novel high-throughput techniques are being used to identify and characterize transcription factor-DNA interactions. Marian Walhout University of Massachussets Amherst USA uses yeast-one hybrid technology to map the protein-DNA interactions in Caenorhabditis elegans neurons. She identified 94 transcription factors which bind the promoters of around 40 neuronal genes. Together with previously published .