tailieunhanh - Báo cáo khoa học: Protein kinase Ce: the mitochondria-mediated signaling pathway

Mitochondria, which are the cellular energy plants, also act as the integra-tion center of cellular signaling pathways. Apoptosis is a well-known pathway in which mitochondria are involved. Protein kinase Cehas been classified as a novel type of protein kinase C and is involved in many cellular events regulating mitochondrial function. | ỊFEBS Journal MINIREVIEW Protein kinase Ce the mitochondria-mediated signaling pathway Hiromichi Yonekawa and Yoshiko Akita Department of Laboratory AnimalScience The Tokyo Metropolitan Institute of MedicalScience Japan Keywords apoptosis Bcl-2 family proteins cardiolipin ischemia mitochondria PKCe PMPT phospholipid scramblase 3 ROS TRAIL Correspondence H. Yonekawa Department of Laboratory AnimalScience The Tokyo Metropolitan Institute of MedicalScience 3-18-22 Honkomagome Bunkyo-ku Tokyo 113-8613 Japan Fax 81 3 3824 7445 Tel 81 3 3823 2105 E-mail yonekawa-hr@ Mitochondria which are the cellular energy plants also act as the integration center of cellular signaling pathways. Apoptosis is a well-known pathway in which mitochondria are involved. Protein kinase Ce has been classified as a novel type of protein kinase C and is involved in many cellular events regulating mitochondrial function. Much evidence has accumulated regarding the relationships between mitochondria-mediated apoptosis and protein kinase Ce. Therefore by focusing on these relationships in particular the anti-apoptotic effects of protein kinase Ce on mitochondrial function we highlight the importance and significance of protein kinase Ce in cell survival and death. Received 12 February 2008 revised 23 May 2008 accepted 30 May 2008 doi PKCe and apoptosis Two isoforms of a novel type of protein kinase C PKC PKCỖ and PKCe show opposing effects on apoptosis. For example activation of PKCỖ induces and or enhances the apoptotic events that occur during ischemic reperfusion and malignant progression of cancer cells whereas activation of protein kinase Ce PKCe inhibits and or reduces these events 1 . Later in this review we will focus much more on the effects of PKCe in apoptosis. PKCe acts as an oncogene with anti-apoptotic effects when PKCe is overexpressed in cancer cells. Overexpression of PKCe in rat fibroblasts has indi cated that those clones expressing