tailieunhanh - Báo cáo y học: "Eukaryotic large nucleo-cytoplasmic DNA viruses: Clusters of orthologous genes and reconstruction of viral genome evolution"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Eukaryotic large nucleo-cytoplasmic DNA viruses: Clusters of orthologous genes and reconstruction of viral genome evolution | Virology Journal BioMed Central Research Eukaryotic large nucleo-cytoplasmic DNA viruses Clusters of orthologous genes and reconstruction of viral genome evolution Natalya Yutin1 Yuri I Wolf1 Didier Raoult2 and Eugene V Koonin 1 Open Access Address National Center for Biotechnology Information National Library of Medicine National Institutes of Health Bethesda MD 20894 USA and 2URMITE Centre National de la Recherche Scientifique UMR IRD 6236 Faculté de Médecine Université de la Méditerranée 27 Boulevard Jean Moulin 13385 Marseille Cedex 5 France Email Natalya Yutin - yutin@ Yuri I Wolf-wolf@ Didier Raoult - Eugene VKoonin - koonin@ Corresponding author Published 17 December 2009 Virology Journal 2009 6 223 doi I743-422X-6-223 Received 27 October 2009 Accepted 17 December 2009 This article is available from http content 6 1 223 2009 Yutin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The Nucleo-Cytoplasmic Large DNA Viruses NCLDV comprise an apparently monophyletic class of viruses that infect a broad variety of eukaryotic hosts. Recent progress in isolation of new viruses and genome sequencing resulted in a substantial expansion of the NCLDV diversity resulting in additional opportunities for comparative genomic analysis and a demand for a comprehensive classification of viral genes. Results A comprehensive comparison of the protein sequences encoded in the genomes of 45 NCLDV belonging to 6 families was performed in order to delineate cluster of orthologous viral genes. Using previously developed computational methods for .