tailieunhanh - Báo cáo khoa học: " Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission | BioMed Central Virology Journal Research Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission Nobubelo K Ngandu 1 Cathal Seoighe2 and Konrad Scheffler3 Address 1National Bioinformatics Node Institute of Infectious Diseases and Molecular Medicine Faculty of Health Sciences University of Cape Town Anzio Road Observatory 7925 South Africa 2School of Mathematics Statistics and Applied Mathematics National University of Ireland Galway Ireland and 3Computer Science Division Dept of Mathematical Sciences University of Stellenbosch Private Bag X1 7602 Matieland South Africa Email Nobubelo K Ngandu - nobubelo@ Cathal Seoighe - Konrad Scheffler - kscheffler@ Corresponding author Open Access Published 10 October 2009 Received I September 2009 Accepted 10 October 2009 Virology Journal 2009 6 164 doi 1743-422X-6-164 This article is available from http content 6 1 164 2009 Ngandu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The cytotoxic T-lymphocyte immune response is important in controlling HIV-1 replication in infected humans. In this immune pathway viral peptides within infected cells are presented to T-lymphocytes by the polymorphic human leukocyte antigens HLA . HLA alleles exert selective pressure on the peptide regions and immune escape mutations that occur at some of the targeted sites can enable the virus to adapt to the infected host. The pattern of ongoing immune escape and reversion associated with several human HLA alleles has been studied extensively. Such mutations revert upon transmission to a host .