tailieunhanh - Báo cáo khoa học: "Human stool contains a previously unrecognized diversity of novel astroviruses"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Human stool contains a previously unrecognized diversity of novel astroviruses | BioMed Central Virology Journal Open Access Short report Human stool contains a previously unrecognized diversity of novel astroviruses Stacy R Finkbeined1 Lori R Holtz12 Yanfang Jiang1 Priya Rajendran3 Carl J Franz1 Guoyan Zhao1 Gagandeep Kang3 and David Wang 1 Address Departments of Molecular Microbiology and Pathology Immunology Washington University School of Medicine St Louis MO USA 2Department of Pediatrics Washington University School of Medicine St Louis MO USA and 3Department of Gastrointestinal Sciences Christian Medical College Vellore India Email Stacy R Finkbeiner - Lori R Holtz - holtz_l@ Yanfang Jiang - jiang@ Priya Rajendran - priyaarajendran@ Carl J Franz - franzcj@ Guoyan Zhao - gzhao@ Gagandeep Kang - gkang@ David Wang - davewang@ Corresponding author fEqual contributors Published 8 October 2009 Received 24 August 2009 Accepted 8 October 2009 Virology Journal 2009 6 161 doi 1743-422X-6-161 This article is available from http content 6 1 161 2009 Finkbeiner et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Human astroviruses are a leading cause of gastrointestinal disease. Since their discovery in 1975 8 closely related serotypes have been described in humans and more recently two new astrovirus species astrovirus MLB1 and astrovirus VA1 were identified in diarrhea patients. In this study we used consensus astrovirus primers targeting the RNA polymerase to define the diversity of astroviruses present in pediatric patients with diarrhea on two continents. From 416 stool specimens comprising two different cohorts from Vellore India 35 samples were