tailieunhanh - Springer Theses Recognizing Outstanding Ph.D. Research

Tumor suppressor protein p53 plays a central role in maintaining genomic integrity [1–3]. In unstimulated cells p53 is maintained at very low levels but in response to DNA damage or other stress stimuli, such as hypoxia or activation of oncogenes, p53 becomes stabilized and accumulates in the cell [4, 5]. p53 can exert its tumor suppressor function in different ways (Fig. ). It can function as a transcription factor that binds to the promoters of many target genes, such as p21, mdm2, puma and bax, thereby elevating or repressing their expression levels to induce cell cycle arrest and apoptosis. Nuclear and cytoplasmic p53 also physically interact with many. | Springer Theses Recognizing Outstanding . Research For further volumes http series 8790 Aims and Scope The series Springer Theses brings together a selection of the very best . theses from around the world and across the physical sciences. Nominated and endorsed by two recognized specialists each published volume has been selected for its scientific excellence and the high impact of its contents for the pertinent field of research. For greater accessibility to non-specialists the published versions include an extended introduction as well as a foreword by the student s supervisor explaining the special relevance of the work for the field. As a whole the series will provide a valuable resource both for newcomers to the research fields described and for other scientists seeking detailed background information on special questions. Finally it provides an accredited documentation of the valuable contributions made by today s younger generation of scientists. Theses are accepted into the series by invited nomination only and must fulfill all of the following criteria They must be written in good English. The topic should fall within the confines of Chemistry Physics Earth Sciences and related interdisciplinary fields such as Materials Nanoscience Chemical Engineering Complex Systems and Biophysics. The work reported in the thesis must represent a significant scientific advance. If the thesis includes previously published material permission to reproduce this must be gained from the respective copyright holder. They must have been examined and passed during the 12 months prior to nomination. Each thesis should include a foreword by the supervisor outlining the significance of its content. The theses should have a clearly defined structure including an introduction accessible to scientists not expert in that particular field. Rui Kamada Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 Doctoral Thesis accepted by .