tailieunhanh - Báo cáo khoa học: "Open Access Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years"

Tham khảo tài liệu 'báo cáo khoa học: "open access genetic diversity and evolution of human metapneumovirus fusion protein over twenty years"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Research Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years Chin-Fen Yang44 Chiaoyin K Wang44 Sharon J Tollefson1 Rohith Piyaratna1 Linda D Lintao4 Marla Chu4 Alexis Liem4 Mary Mark4 Richard R Spaete4 James E Crowe Jr1 2 3 and John V Williams 1 2 3 Address Department of Pediatrics Vanderbilt University School of Medicine Nashville TN USA 2Monroe Carell Jr Children s Hospital at Vanderbilt Nashville TN USA 3Department of Microbiology and Immunology Vanderbilt University School of Medicine Nashville TN USA and 4MedImmune Vaccines Inc Mountain View CA USA Email Chin-Fen Yang - yangc@ Chiaoyin K Wang - wangk@ Sharon J Tollefson - Rohith Piyaratna - Linda D Lintao - lintaol@ Marla Chu - chum@ Alexis Liem - liema@ Mary Mark - markm@ Richard R Spaete - delta_gee@ James E Crowe - John V Williams - Corresponding author fEqual contributors Open Access Published 9 September 2009 Virology Journal 2009 6 138 doi I743-422X-6-I38 Received 27 July 2009 Accepted 9 September 2009 This article is available from http content 6 1 138 2009 Yang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Human metapneumovirus HMPV is an important cause of acute respiratory illness in children. We examined the diversity and molecular evolution of HMPV using 85 full-length F fusion gene sequences collected over a 20-year period. Results The F gene sequences