tailieunhanh - Báo cáo y học: "How soon to start: aspirin resumption after upper gastrointestinal bleed"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: How soon to start: aspirin resumption after upper gastrointestinal bleed? | Gooch and Baldisseri Critical Care 2010 14 331 http content 14 6 331 CRITICAL CARE JOURNAL CLUB CRITIQUE L How soon to start aspirin resumption after upper gastrointestinal bleed Rebecca Gooch and Marie Baldisseri University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club edited by Sachin Yende Extended abstract Citation Continuation of low-dose aspirin therapy in peptic ulcer bleeding a randomized trial. Sung JJ Lau JY Ching JY Wu JC Lee YT Chiu PW Leung VK Wong VW Chan FK. Ann Intern Med. 2010 Jan 5 152 1 1-9. Epub 2009 Nov 30. Background It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin. Objective To test that continuing aspirin therapy with protonpump inhibitors after endoscopic control of ulcer bleeding was not inferior to stopping aspirin therapy in terms of recurrent ulcer bleeding in adults with cardiovascular or cerebrovascular diseases. Design A parallel randomized placebo-controlled noninferiority trial in which both patients and clinicians were blinded to treatment assignment was conducted from 2003 to 2006 by using computer-generated numbers in concealed envelopes. registration number NCT00153725 Setting A tertiary endoscopy center. Patients Low-dose aspirin recipients with peptic ulcer bleeding. Intervention 78 patients received aspirin 80 mg d and 78 received placebo for 8 weeks immediately after endoscopic Correspondence baldisserimr@ department of Critical Care Medicine University of Pittsburgh 614 Scaife Hall 3550 Terrace Street Pittsburgh PA 15261 USA 2 BioMed Central 2010 BioMed Central Ltd therapy. All patients received a 72-hour infusion of pantoprazole followed by oral pantoprazole. All patients completed follow-up. Measurements The primary end point was recurrent ulcer bleeding within 30 days confirmed by endoscopy. .