tailieunhanh - Báo cáo y học: "Molecular epidemiology of Hepatitis C virus genotypes in Khyber Pakhtoonkhaw of Pakistan"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Molecular epidemiology of Hepatitis C virus genotypes in Khyber Pakhtoonkhaw of Pakistanb | Ali et al. Virology Journal 2010 7 203 http content 7 1 203 VIROLOGY JOURNAL RESEARCH Open Access Molecular epidemiology of Hepatitis C virus genotypes in Khyber Pakhtoonkhaw of Pakistan Amjad Ali1 Habib Ahmed1 Muhammad Idrees2 Abstract Six major Hepatitis C virus HCV genotypes and hundreds of subtypes have been identified globally. All these genotypes are generally studied for epidemiology their vaccine development and clinical management. This article comments the frequency distribution of various HCV genotypes circulate in different areas districts of Khyber Pakh-toonkhaw Province of Pakistan. Sum of 415 HCV RNA PCR positive sera samples were tested by a molecular genotyping assay. Data analysis revealed that out of these 415 HCV RNA positive patients 243 were males and 172 were females. Distribution breakup of the patients was 135 58 51 51 36 32 6 7and 9 patients come from the districts of Abbottabad Mardan Pehawar Swat Haripure Swabi and Dera Ismail Khan respectively. Out of the tested samples genotype specific PCR fragments were observed in 299 patient serum samples. The distribution of genotypes of the typeable samples was as fallows 3 patients each were infected with genotype 1a and genotype 1b 240 patients of genotype 3a 25 patients genotype 3b and 28 patients were observed as with mixed genotypic infection. Sums of 116 serum samples were still found untypeable by the used molecular genotyping system. In conclusion HCV genotypes 1a 1b 3a and 3b are distributed in various parts of KPK among which the genotype 3a is the most frequent genotype. Background Hepatitis C virus HCV infection is accountable for the second most common cause of viral hepatitis and is one of the most important Flaviviridae infections with significant clinical problems all over the globe in humans 1 . At least six major HCV genotypes and hundreds of subtypes have been identified worldwide so far 2 . Dissimilar HCV genotypes are related