tailieunhanh - Báo cáo y học: " Dental problems delaying the initiation of interferon therapy for HCV-infected patients"

Dental problems delaying the initiation of interferon therapy for HCV-infected patients | Nagao and Sata Virology Journal 2010 7 192 http content 7 1 192 VIROLOGY JOURNAL RESEARCH Open Access Dental problems delaying the initiation of interferon therapy for HCV-infected patients Yumiko Nagao1 Michio Sata1 2t Abstract Background There has been little discussion about the importance of oral management and interferon IFN therapy although management of the side effects of therapy for chronic hepatitis C has been documented. This study determined whether dental problems delayed the initiation of IFN therapy for hepatitis C virus HCV -infected patients. Results We analyzed 570 HCV-infected patients who were admitted to our hospital from December 2003 to June 2010 for treatment consisting of pegylated IFN Peg-IFN monotherapy or Peg-IFN ribavirin combination therapy. The group comprised 274 men and 296 women with a mean age years. Of the 570 patients six could not commence Peg-IFN therapy despite their admission because of dental problems such as periodontitis pupitis and pericoronitis. The ages of six whose dental problems delayed the initiation of Peg-IFN ranged from 25 to 67 years with a mean age of years. IFN therapy was deferred for days. Among the six subjects for whom IFN treatment was delayed only one had a salivary flow that was lower than the normal value. Conclusions Treatment of dental infections is required before IFN therapy for HCV infection can be started. To increase the depth of understanding of oral health care it is hoped that dentists and medical specialists in all areas will hold discussions to generate cooperation. Background In Japan hepatocellular carcinoma HCC is the fourth leading cause of death in males and the sixth in females according to a recent survey. The incidence of HCC has increased in Japan throughout the past several decades 1 . Hepatitis C virus HCV is the major cause of HCC in Japan with 70 of cases being HCV-related. It is assumed that b etwe en one and two million Japanese .

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