tailieunhanh - NEJM CARDIOVASCULAR DISEASE ARTICLES - Part 8

Đặc điểm lâm sàng cơ bản Theo các phân suất tống máu thất trái (LVEF) và hiện diện hay vắng mặt của bệnh lâm sàng đáng kể động mạch vành (CAD) .* Đặc tính CAD (N = 152) Tuổi (năm) trung bình khoảng tứ phân vị | The new ENGLAND journal of medicine Table 2. Baseline Clinical Characteristics According to the Left Ventricular Ejection Fraction LVEF and the Presence or Absence of Clinically Significant Coronary Artery Disease CAD . Characteristic LVEF 60 LVEF 60 No CAD N 152 CAD N 354 P Value No CAD N 55 CAD N 473 P Value Age yr Median 56 59 54 59 Interquartile range 47-63 52-65 46-67 54-66 Male sex 33 76 62 84 Family history of ischemic heart disease 38 40 16 33 Medical history Suspected heart failure 69 52 67 63 NYHA functional class I 13 22 17 17 II 64 60 35 58 III 17 15 48 21 IV 6 3 0 3 Hypertension 26 34 20 32 Diabetes 13 19 15 22 Previous myocardial infarction 17 43 43 73 Peripheral vascular disease 11 11 11 15 Cerebrovascular disease 8 6 2 5 Hypercholesterolemia 31 41 27 38 Angina pectoris 89 93 63 90 CCS class I 26 23 20 20 II 45 45 45 41 III 24 28 25 36 IV 5 4 10 6 Previous PTCA 0 Previous CABG 6 2 9 verity of coronary artery disease as having no clinically significant disease one- two- or three-vessel disease or disease of the left main coronary artery. Patients with three-vessel and left main coronary artery disease had similar mortality rates and were therefore combined into one group in the regression analysis. Analyses were performed with NT-pro-BNP in quartiles as a categorical variable with the lowest quartile serving as reference for the other three quartiles. A backward-elimination model was applied. Tests were two-sided and a P value of less than was considered to indicate statistical significance. All calculations were generated by SAS software version . RESULTS demographic characteristics After a median follow-up of years 288 of the 1034 patients 28 percent had died. The median NT-pro-BNP level for all subjects was elevated 169 pg per milliliter interquartile range 63 to 456 and was .