tailieunhanh - Báo cáo y học: "High prevalence of porcine Hokovirus in German wild boar populations"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: High prevalence of porcine Hokovirus in German wild boar populations | Adlhoch et al. Virology Journal 2010 7 171 http content 7 1 171 VIROLOGY JOURNAL SHORT REPORT Open Access High prevalence of porcine Hokovirus in German wild boar populations 1 1 1 Cornelia Adlhoch Marco Kaiser Heinz Ellerbrok Georg Pauli Abstract Porcine Hokovirus PHoV was recently discovered in Hong Kong. This new Parvovirus of pigs is closely related to the human Parvoviruses 4 and 5 PARV4 5 and bovine Hokovirus BHoV . So far nothing is known about the presence and prevalence of PHoV in regions of the world other than Hong Kong. A study was initiated to investigate PHoV in German wild boars from five different geographical regions using a newly established quantitative real-time PCR assay. Analysis of collected liver and serum samples revealed high overall prevalence 51 156 of PHoV in wild boars. The prevalence differed between the regions and increased with age. Two near full-length genomes and a large fragment for three additional isolates from different regions were sequenced and used for phylogenetic analysis. The German PHoV sequences from wild boars showed a close relationship with sequences of isolates from Hong Kong. Findings A broad spectrum of parvoviruses is circulating worldwide in different species causing diseases in animals and humans. One of several novel animal parvoviruses is the porcine Hokovirus PHoV a putative member of the genus Parvovirus within the family of Parvoviridae. This new parvovirus PHoV has been described in pigs from Hong Kong 1 . The non-enveloped parvovirus harbours a single-stranded DNA genome of approximately 5 kb. The genome has two open reading frames ORFs coding for non-structural and capsid proteins. Closely related human Parvoviruses PARV 4 and PARV5 were detected in various samples from healthy and diseased individuals 2-5 . Up to now no information is available about the presence of PHoV in other pig populations. This study was initiated to analyse PHoV in German wild boars. Wild boars in .