tailieunhanh - Báo cáo y học: "High-risk human papillomavirus in the oral cavity of women with cervical cancer, and their children"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: High-risk human papillomavirus in the oral cavity of women with cervical cancer, and their children | Saini et al. Virology Journal 2010 7 131 http content 7 1 131 VIROLOGY JOURNAL RESEARCH Open Access High-risk human papillomavirus in the oral cavity of women with cervical cancer and their children I-X I- 1 1 1 1 2 Rajan Saini Tan P Khim Sarah A Rahman Mazian Ismail Thean H Tang Abstract Background Association of High-risk Human Papillomavirus HR-HPV with oral cancer has been established recently. Detecting these viruses in oral cavity is important to prevent oral lesions related to them. The purpose of this study was to evaluate the prevalence of HR-HPV in the oral cavity of women with cervical cancer and their children. A total of 70 women previously diagnosed with cervical cancer and 46 children of these women born by vaginal delivery only were selected for this study. Buccal swabs were collected from their oral cavity and HPV detection was carried out using Hybrid Capture 2 high-risk HPV HC2 HR-HPV detection system. Results Out of 70 women with cervical cancer four were found to be positive for HR-HPV in their oral cavity. No association of HR-HPV was found with sociodemographic profile marital status reproductive history tobacco and alcohol usage contraceptive pills usage and presence of oral lesions p . Among children HR-HPV in the oral cavity was detected in only 1 of the 46 subjects examined . Clinically healthy oral mucosa without any oral lesions was observed in all the HR-HPV positive subjects. Conclusion The result of this study showed that there is low if any risk of HR-HPV infection in the oral cavity of women with cervical cancer. Further our study suggests that there is very low risk for children of women with cervical cancer to acquire and sustain HR-HPV in their oral cavity until childhood or adolescence. Background Human Papillomavirus HPV is an epitheliotropic double stranded circular DNA virus from Papovavirus family 1 which is found to infect cells in the basal layer of squamous epithelium 2 . Thus infection .