tailieunhanh - Perioperative Critical Care Cardiology - part 3

đánh giá và quản lý rủi ro chu phẫu của bệnh động mạch vành liên quan đến phẫu thuật không do tim lớn và đề nghị rằng tất cả các bệnh nhân hội đủ điều kiện sẽ nhận được một β-blocker (atenolol) trong giai đoạn chu phẫu | Cardiac Protection for Noncardiac Surgery 49 assessing and managing the perioperative risk of coronary artery disease associated with major noncardiac surgery and recommended that all eligible patients should receive a p-blocker atenolol during the perioperative period 42 . This recommendation was based on the large body of evidence of the efficacy of p-blockade in medical patients and the more limited evidence in surgical patients. Later this recommendation was reinforced by the results of a study by Poldermans and colleagues 7 . These authors studied high-risk vascular surgical patients selected because of the presence of reversible ischemia on dobutamine-sensitized echocardiography a finding indicative of significant coronary artery disease . Patients were randomized to receive active treatment or conventional management. The active treatment was with bisopro-lol started a week or more before surgery and continued for 30 days postop-eratively. At 30 days the results were highly positive p-blockade caused a large reduction in cardiac death versus 17 in the control group and nonfatal myocardial infarction 0 versus 17 in the control group . Significant benefits continued to be observed during a 2-year follow-up. As all patients were at a particularly high risk for coronary events 34 combined incidence of cardiac death and nonfatal myocardial infarction in the conventional treatment group the efficacy of p-blockade in this study cannot be extrapolated to patients at risk for coronary disease rather than with demonstrably severe coronary artery disease. p-Blockade seems to be the logical answer to the perioperative drug management of patients with coronary artery disease or risk factors for coronary artery disease. Indeed as early as 1988 an editorial in Anesthesiology was entitled Should we all have a sympathectomy at birth or at least preoperatively 43 . More importantly several systematic reviews have concluded its efficacy 16 44 45 . Why then are p-blockers .

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