tailieunhanh - Neonatal Formulary - part 10

thường được giải quyết mà không cần điều trị. Cocaine Một số vẫn còn trong sữa mẹ trong 24 giờ sau khi sử dụng mẹ, nhưng hiệu quả sử dụng trong thời kỳ cho con bú không có vẻ đã được nghiên cứu một cách chi tiết. | Maternal medication and the baby usually settles without treatment. Some cocaine persists in breast milk for 24 hours after maternal use but the effect of use during lactation does not seem to have been studied in any detail. There seems to be an associated increase in the risk of sudden infant death cot death . Behnke Pediatrics 2001 107 e74. Bauer Arch Pediatr Adolesc Med 2005 159 824. Colchicine M P ratio 1 Infant dose 2-8 Colchicine is mostly used to treat familial Mediterranean fever and gout. Aminocentesis or chorion villus biopsy should be offered to mothers on colchicine at conception because of possible cytogenicity. The few reports of use during lactation suggest that only modest amounts of colchicine reach the baby although there is one unconfirmed report of neonatal toxicity. Rabinovitch Am J Reprod Immunol 1992 28 245. Ben-Chetrit SeminArthitisRheum 1998 28 48. Co-phenotrope Lomotil which contains 100 parts of diphenoxylate hydrochloride to 1 part of atropine sulphate is widely used in many parts of the world to control diarrhoea. Very little is known about use during pregnancy or lactation - loperamide . is a much better studied alternative. Excessive Lomotil use in young children is potentially extremely hazardous the diphenoxylate causing a delayed opiate collapse. Corticosteroids Pregnancy-associated hypertension is more likely to develop in women who take oral steroids during pregnancy but this does not seem to happen to those taking an inhaled corticosteroid. For a comment on the fetal consequences of taking steroids during pregnancy see the entry under prednisolone. Martel bMj2005 330 230. Cough and cold remedies Many compound proprietary medicines are available over the counter . Avoid formulations with ingredients of the type mentioned in the commentary on antihistamines . . Pseudo-ephedrine use reduces prolactin levels and might therefore impair lactation. Cyclophosphamide This anticancer drug would seem to be teratogenic when given in