tailieunhanh - CLINICIAN’S POCKET DRUG REFERENCE 2008 - part 3

Tránh thuốc chống đông máu, chảy máu ↑ nguy cơ; TRÁNH sử dụng w / tan huyết khối Contra: Công khai của chính bị chảy máu Disp: inj 100 mg / mL SE: AF, ngừng tim, rối loạn mạch máu não, ↓ BP, VT , N / V / D, nhiễm trùng huyết, ho, thận tox, ↓ HGB Lưu ý: | 42 Aripiprazole w hepatic impair Caution B Avoid PO anticoagulants T bleeding risk avoid use w thrombolytics Contra Overt major bleed Disp Inj 100 mg mL SE AF cardiac arrest cerebrovascular disorder ị BP VT N V D sepsis cough renal tox ị Hgb Note Steady state in 1-3 h Aripiprazole Abilify WARNING Increased mortality in elderly with dementia-related psychosis Uses Schizophrenia Action Dopamine serotonin antagonist Dose Adults. 10-15 mg PO daily mg for acute agitation ị dose w CYP3A4 CYP2D6 inhibitors Table 11 T dose w CYP3A4 inducer Caution C - Disp Tabs 2 5 10 15 20 30 mg Discmelt disint. tabs 10 15 20 30 mg soln 1 mg ml inj mg mL SE Neuroleptic malignant synd tardive dyskinesia orthostatic ị BP cognitive motor impair T glucose Artificial Tears Tears Naturale OTC Uses Dry eyes Action Ocular lubricant Dose 1-2 gtt tid-qid Disp OTC soln L-Asparaginase Elspar Oncaspar Uses ALL in combo w other agents Action Protein synth inhibitor Dose 500-20 000 IU m2 d for 1-14 d Per protocols Caution C Contra Active Hx pancreatitis Disp Inj powder for recons 10 000 units SE Allergy 20-35 urticaria to anaphylaxis rare GI tox mild N anorexia pancreatitis T glucose coagulopathy Notes test dose recommended glucose coags Aspirin Bayer Ecotrin St. Joseph s OTC Uses Angina CABG PTCA carotid endarterectomy ischemic stroke TIA MI arthritis pain HA fever inflammation Kawasaki Dz Action Prostaglandin inhibitor Dose Adults. Pain fever 325-650 mg q4-6h PO or PR. RA 3-6 g d PO in doses. Pit inhibitor 81-325 mg PO daily. Prevent MI 81 preferred -325 mg PO daily. Acute Coronary Syndrome ECC 2005 160-325 mg PO ASAP chewing preferred at onset Peds. Antipyretic 10-15 mg kg dose PO or PR q4h up to 80 mg kg 24 h. RA 60-100 mg kg 24 h PO q4-6h keep levels 15-30 mg dL avoid w CrCl 10 mL min severe liver Dz Caution C M Linked to Reye s synd avoid w viral illness in children Contra Allergy to ASA chickenpox flu Sxs synd of nasal polyps angioedema bronchospasm to NSAIDs Disp Tabs 325 500 mg chew