tailieunhanh - Báo cáo khoa học: Peroxisomes as dynamic organelles: peroxisome abundance in yeast

Peroxisomes are cell organelles that are present in almost all eukaryotic cells and involved in a large range of metabolic pathways. The organelles are highly dynamic in nature: their number and enzyme content is highly variable and continuously adapts to prevailing environmental conditions. This review summarizes recent relevant developments in research on pro-cesses that are involved in the regulation of peroxisome abundance and maintenance. | ỊFEBS Journal MINIREVIEW Peroxisomes as dynamic organelles peroxisome abundance in yeast Ruchi Saraya Marten Veenhuis and Ida J. van der Klei Molecular CellBiology Groningen Biomolecular Sciences and Biotechnology Institute GBB University of Groningen Kluyver Centre for Genomics of IndustrialFermentation Haren The Netherlands Keywords de novo synthesis fission organelle inheritance peroxisomes yeast Correspondence I. J. van der Klei Molecular CellBiology Groningen Biomolecular Sciences and Biotechnology Institute GBB PO Box 14 NL-9750 AA Haren The Netherlands Fax 31 0 50 363 8280 Tel 31 0 50 363 2179 E-mail Peroxisomes are cell organelles that are present in almost all eukaryotic cells and involved in a large range of metabolic pathways. The organelles are highly dynamic in nature their number and enzyme content is highly variable and continuously adapts to prevailing environmental conditions. This review summarizes recent relevant developments in research on processes that are involved in the regulation of peroxisome abundance and maintenance. These processes include fission of the organelles formation of new peroxisomes from the endoplasmic reticulum autophagic degradation and segregation inheritance during cell division. Received 2 March 2010 revised 23 April 2010 accepted 17 May 2010 doi Introduction Eukaryotic cells are characterized by the presence of specific compartments the organelles. The advantages of compartmentalization may include the creation of unique microenvironments with specific bio chemical properties to improve the efficiency of certain processes or to provide additional pathways for regulation. To form and maintain these compartments highly complex mechanisms exist in eukaryotic cells. Peroxisomes represent an important class of organelles that are present in almost all eukaryotes 1 . Their function and significance varies with the organism in which they occur their developmental stage