tailieunhanh - Báo cáo khoa học: BRCA1 16 years later: nuclear import and export processes

Over the past several years, the importance of regulated nuclear transport processes for tumor suppressors has become evident. Proteins with a molecular mass greater than 40 kDa can enter the nucleus only by active transport across the nuclear membrane. The most common pathway by which this occurs is via the importin alpha⁄beta pathway, whereby the cargo protein binds importin alpha. | MINIREVIEW BRCA1 16 years later nuclear import and export processes Marilyn E. Thompson Department of PharmaceuticalSciences Schoolof Pharmacy Belmont University Nashville TN USA Keywords BRCA1-associated RING domain protein 1 BARD1 breast cancer susceptibility gene 1 BRCA1 nuclear export nuclear export sequence nuclear import nuclear localization signal RING finger Correspondence M. E. Thompson Department of Pharmaceutical Sciences School of Pharmacy Belmont University 1900 Belmont Blvd. Nashville TN 37212 USA Fax 615 460 6537 Tel 615 460 8121 E-mail Website http pharmacy Received 7 July 2009 revised 27 April 2010 accepted 26 May 2010 doi Over the past several years the importance of regulated nuclear transport processes for tumor suppressors has become evident. Proteins with a molecular mass greater than 40 kDa can enter the nucleus only by active transport across the nuclear membrane. The most common pathway by which this occurs is via the importin alpha beta pathway whereby the cargo protein binds importin alpha. This heterodimer binds importin beta and the heterotrimer passes through nuclear pores at the expense of GTP. Breast cancer susceptibility gene 1 BRCA1 is one such protein. As a mediator of transcription and DNA repair two exclusively nuclear functions BRCA1 at 220 kDa can enter the nucleus only via active transport mechanisms. In addition to the classical importin alpha beta pathway BRCA1 can also enter the nucleus in a piggyback mechanism with BRCA1-associated RING domain protein 1 BARD1 . The interaction between BRCA1 and BARD1 is also important in the retention of BRCA1 in the nucleus. This is important because BRCA1 also undergoes active nuclear export. BRCA1 is also involved in apoptotic processes. Whether this occurs within the nucleus or cytoplasm is still unclear thus the consequences of BRCA1 nuclear export have not been clearly elucidated. This review will discuss the

• Báo cáo khoa học
• Scientific reports
• scientific research
• biochemistry
• molecular Biology
• tumor cells
• Antimicrobial
• Nelson’s pediatric antimicrobial therapy
• Choosing among antifungal agents
• Antimicrobial therapy for newborns
• Antimicrobial therapy according
• Clinical syndromes
• Beta lactamase inhibitors
• Antimicrobial therapy
• Mycobacterial pathogens
• Specific bacterial
• Nosocomial infection
• Hospital acquired infection
• Prevalence and antimicrobial susceptibility pattern
• Antimicrobial susceptibility pattern
• Evaluate antimicrobial susceptibility pattern
• Antimicrobial properties
• Antimicrobial activity
• Phyo chemical analysis
• Plant resources having antimicrobial properties obtained
• Phytochemical analysis of plant resources
• Antimicrobial activity of ZITRITIDE
• Organic antimicrobial fogging solution
• Special reference
• Infection prevention
• Hospital environments
• Other clean room facilities
• Specific parasitic pathogens
• Antimicrobial susceptibility
• Changing antimicrobial susceptibility pattern
• Pus samples
• Susceptibility pattern
• Antimicrobial susceptibility testing
• BMC Veterinary Research
• Antimicrobial usage
• Antimicrobial resistance
• Salmonella spp
• Alphabetic listing of antimicrobials
• Adverse reactions to antimicrobial agents
• Drug interactions
• Antibiotic therapy
• Alphabetic listing
• Symptomatic infection
• Antimicrobial prophylaxis
• Adverse reactions
• Lecture Microbiology
• Roles of microbes
• Biological research
• Antimicrobial drug properties
• Drug target sites
• Journal of Chemistry
• The Chemistry and Antimicrobial Activity of Psychotria reevesii Wall
• The Chemistry and Antimicrobial Activity
• Psychotria reevesii Wall
• The polar fractions against Staphylococcus aureus
• Journal of medical research
• Prevalence of antimicrobial resistance of neisseria gonorrhoeae
• Antimicrobial resistance of neisseria gonorrhoeae
• National hospital of dermatology and venereology in 2017
• Minimum inhibitory concentration
• Antimicrobial compound
• Burkholderia paludis
• Enterococcus faecalis
• The role of reactive oxygen species
• Pentafluorophenylammonium triflate
• Coumarin 3 carboxylic acid
• Chromeno[2 3 d]pyrimidinones
• 4H pyran 5 ethylcarboxylate
• Green synthesis
• Characterization and antimicrobial evaluation
• Antimicrobial evaluation
• Nano silver
• Mastitis causing microorganisms
• Bacterial profile
• Ventilator associated pneumonia
• BMC Pediatrics
• Pediatric community acquired pneumonia
• Community acquired pneumonia
• Empiric antimicrobial choice
• Heightened antimicrobial stewardship
• Virulence genes
• Identification and antimicrobial resistance
• Enterococcus faecalis isolated
• Diabetic foot patients
• ESKAPE pathogens
• Multidrug resistant (MDR) bacteria
• Tertiary care centre
• Antimicrobial susceptibility profile
• Clinical importance
• Staphylococcus aureus
• Hadman farm dairies
• Antimicrobial susceptibility test
• Cheese from Hadman farm dairies
• BMC Pharmacology and Toxicology
• MDR Salmonella
• Antimicrobial resistant Salmonella
• Pan resistance
• Drug sensitivity
• Amhara National Regional State
• Clinical microbiology laboratories
• Risk factors
• Mount Sinai Beth Israel
• Outpatient parenteral antimicrobial therapy
• Bacillus firmicutes
• Biopeptide or Bacterio cin
• Food borne pathogens