tailieunhanh - Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases

Obesity and related metabolic diseases, such as type 2 diabetes, hyperten-sion and hyperlipidemia are an increasingly prevalent medical and social problem in developed and developing countries. These conditions are asso-ciated with increased risk of cardiovascular disease, the leading cause of death. | IFEBS Journal MINIREVIEW Angiopoietin-like proteins emerging targets for treatment of obesity and related metabolic diseases Tsuyoshi Kadomatsu Mitsuhisa Tabata and Yuichi Oike Department of Molecular Genetics Graduate Schoolof MedicalSciences Kumamoto University Japan Keywords adipose tissue ANGPTL2 ANGPTL6 AGF cardiovascular disease chronic inflammation energy metabolism insulin resistance metabolic syndrome obesity obesity-related metabolic disease Correspondence Y. Oike Department of Molecular Genetics Graduate School of Medical Sciences Kumamoto University 1-1-1 Honjo Kumamoto 860-8556 Japan Fax 81 96 373 5145 Tel 81 96 373 5140 E-mail oike@ Note Tsuyoshi Kadomatsu and Mitsuhisa Tabata contributed equally to this work Received 21 July 2010 revised 21 November 2010 accepted 29 November 2010 doi Obesity and related metabolic diseases such as type 2 diabetes hypertension and hyperlipidemia are an increasingly prevalent medical and social problem in developed and developing countries. These conditions are associated with increased risk of cardiovascular disease the leading cause of death. Therefore it is important to understand the molecular basis underlying obesity and related metabolic diseases in order to develop effective preventive and therapeutic approaches against these conditions. Recently a family of proteins structurally similar to the angiogenic-regulating factors known as angiopoietins was identified and designated angiopoietin-like proteins ANGPTLs . Encoded by seven genes ANGPTL1-7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain both characteristic of angiopoietins. ANGPTLs do not bind to either the angiopoietin receptor Tie2 or the related protein Tiel indicating that these ligands function differently from angiopoietins. Like angiopoietins some ANGPTLs potently regulate angiogenesis but ANGPTL3 -4 and ANG-PTL6 angiopoietin-related growth factor AGF directly .