tailieunhanh - Toxic chemicals and childhood cancer: A review of the evidence

EDRN is at the forefront of technology-driven research on the use of biomarkers for the early detection of cancer. By identifying and validat- ing biomarkers, such as novel proteins or changes in gene expression, it is possible to measure an individual’s disease risk, progression of disease, or response to therapy. Ultimately, EDRN research will aid in prevention and in early therapeutic intervention, based on early detection of disease. Researchers with EDRN have been instrumental in identifying and validating markers for many major cancers, such as prostate (protein profiling of BPH, HPIN and IGFb3/br), colon (K-ras mutations in stool and urine). | Toxic chemicals and childhood cancer A review of the evidence Tami Gouveia-Vigeant MPH MSW and Joel Tickner ScD With contributions from Richard Clapp DSc1 May 2003 A Publication of the Lowell Center for Sustainable Production University of Massachusetts Lowell One University Avenue Lowell MA 01854 978-934-2981 The Lowell Center for Sustainable Production The Lowell Center for Sustainable Production develops studies and promotes environmentally sound systems of production healthy work environments and economically viable work organizations. The Center operates on the premise that environmental quality safe and healthy workplaces and social accountability can be achieved while at the same time enhancing the economic life of firms. This is accomplished by broadening the fundamental design criteria for all productive activities to include an explicit and comprehensive commitment to sustainability. The Center is composed of faculty and staff at the University of Massachusetts Lowell who work directly with industrial firms social service institutions citizen organizations and government agencies to promote sustainable production. Lowell Center for Sustainable Production University of Massachusetts Lowell 1 Department of Environmental Health Boston University School of Public Health 1 EXECUTIVE SUMMARY Childhood cancer is the second largest cause of death to children ages 0-15 in the United States second only to accidents and more than 8 000 cases are diagnosed each year. In Massachusetts from 1990-1999 approximately 2 688 children ages 0-19 were diagnosed with cancer and 394 died. The overall rate of childhood cancer in Massachusetts is slightly higher than the national average new cases versus per 100 000 per year. African American and Latino children in Massachusetts had approximately 25 more diagnosed cancers than white and Asian and Pacific Islander children. Although childhood cancer is a relatively rare disease cancer rates .