tailieunhanh - Biomarkers in Cancer: An Introductory Guide for Advocates

Many people can work during chemotherapy, as long as they match their schedule to how they feel. Whether or not you can work may depend on what kind of work you do. If your job allows, you may want to see if you can work part-time or work from home on days you do not feel well. Many employers are required by law to change your work schedule to meet your needs during cancer treatment. Talk with your employer about ways to adjust your work during chemotherapy. You can learn more about these laws by talking . | Advancing Patient-Focused Research Research Advocacy Network Biomarkers in Cancer An Introductory Guide for Advocates Table of Contents Page Chapter 1 Introduction to Chapter 2 Explanation of Genes and Proteins Common Biomarkers in Chapter 3 Uses of Biomarkers in Chapter 4 Challenges With Biomarkers .29 Chapter 5 The Promise of Biomarkers How Do We Get From Here to There .41 Chapter 6 The Pathway Approach to Biomarker Discovery .53 Chapter 7 Ethical Legal and Social Issues With Chapter 8 How Can Advocates Use This Information .73 BIOMARKERS IN CANCER AN INTRODUCTORY GUIDE FOR ADVOCATES CHAPTER 1. INTRODUCTION TO BIOMARKERS 1 What Are Proteins When we hear the word protein the first thing many of us think of is the protein in the foods we eat. Protein-rich foods include eggs meat cheese beans and nuts. Technically proteins are large complex 3-dimensional molecules made up of hundreds or thousands of smaller components called amino acids. Our bodies take proteins from the foods we eat and break them down into individual amino acids. These amino acids are then reassembled in a different order to form specific proteins that our cells need to maintain their structures and carry out their functions. When we go into our physician s office for an annual check-up we are likely to have our cholesterol levels and blood pressure checked. These procedures are deemed important because high cholesterol is a biomarker for cardiovascular disease and high blood pressure is a biomarker for stroke. In bygone days physicians used to look at the color of their patients urine to determine whether they were healthy. As can be seen from these examples biomarkers have been with us a long time and have become a routine part of medical care. What is a Biomarker Ideally different organizations and publications would agree on the definition of a biomarker. However defining biomarkers is not straightforward .

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