tailieunhanh - Chapter 085. Neoplasms of the Lung (Part 4)

Inherited Predisposition to Lung Cancer While an inherited predisposition to develop lung cancer is not common, several features suggest a potential for familial association. People with inherited mutations in RB (patients with retinoblastomas living to adulthood) and p53 (LiFraumeni syndrome) genes may develop lung cancer. First-degree relatives of lung cancer probands have a two- to threefold excess risk of lung cancer or other cancers, many of which are not smoking-related. An as yet unidentified gene in chromosome region 6q23 was found to segregate in families at high risk of developing lung cancer of all histologic types. Finally, certain polymorphisms. | Chapter 085. Neoplasms of the Lung Part 4 Inherited Predisposition to Lung Cancer While an inherited predisposition to develop lung cancer is not common several features suggest a potential for familial association. People with inherited mutations in RB patients with retinoblastomas living to adulthood and p53 Li-Fraumeni syndrome genes may develop lung cancer. First-degree relatives of lung cancer probands have a two- to threefold excess risk of lung cancer or other cancers many of which are not smoking-related. An as yet unidentified gene in chromosome region 6q23 was found to segregate in families at high risk of developing lung cancer of all histologic types. Finally certain polymorphisms of the P450 enzyme system which metabolizes carcinogens or chromosome fragility mutagen sensitivity genotypes are associated with the development of lung cancer. The use of any of these inherited differences to identify persons at very high risk of developing lung cancer would be useful in early detection and prevention efforts. Therapy Targeted at Molecular Abnormalities A detailed understanding of the molecular pathogenesis should be applicable to new methods of early diagnosis prevention and treatment of lung cancer. Two examples of this translation involve EGFR and vascular endothelial growth factor VEGF . EGFR belongs to the ERBB HER family of protooncogenes including EGFR ERBB1 Her2 neu ERBB2 HER3 ERBB3 and HER4 ERBB4 cell-surface receptors consisting of an extracellular ligandbinding domain a transmembrane structure and an intracellular tyrosine kinase TK domain. The binding of ligand to receptor activates receptor dimerization and TK autophosphorylation initiating a cascade of intracellular events leading to increased cell proliferation angiogenesis metastasis and a decrease in apoptosis Chap. 80 . Overexpression of EGFR protein or amplification of the EGFR gene has been found in as many as 70 of NSCLCs. Activating oncogenic mutations usually a missense or a small .

• Y học thường thức
• Neoplasms of the Lung
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu y khoa
• Harrisons Internal Medicine
• BMC Cancer
• Bone metastases
• Stereotactic radiotherapy
• Neoplasm metastasis
• Lung neoplasms
• Prostatic neoplasms
• Breast neoplasms
• Multivariate analysis
• Bone neoplasms
• Orthopedic surgery
• Lung cancer
• Atlas of pulmonary cytopathology
• Benign lung neoplasms
• Malignant lung neoplasms
• Unusual and metastatic lesions
• Metastatic lesions
• Colorectal neoplasms
• Molecular targeted therapy
• Molecular diagnostics
• Chest radiology
• Upper lung disease
• Peripheral lung disease
• Unilateral hyperlucent hemithorax
• Congenital lung disease
• BMC Pulmonary Medicine
• Diagnostic yields
• Transbronchial lung biopsy
• Radial probe endobronchial ultrasound
• Specific therapeutic interventions
• Multivariate logistic regression model
• Factors significantly