tailieunhanh - Chapter 083. Cancer of the Skin (Part 2)

Clinical Characteristics There are four types of cutaneous melanoma (Table 83-2). In three of these—superficial spreading melanoma, lentigo maligna melanoma, and acral lentiginous melanoma—the lesion has a period of superficial (so-called radial) growth during which it increases in size but does not penetrate deeply. It is during this period that the melanoma is most capable of being cured by surgical excision. The fourth type—nodular melanoma—does not have a recognizable radial growth phase and usually presents as a deeply invasive lesion, capable of early metastasis. When tumors begin to penetrate deeply into the skin, they are in the so-called vertical growth. | Chapter 083. Cancer of the Skin Part 2 Clinical Characteristics There are four types of cutaneous melanoma Table 83-2 . In three of these superficial spreading melanoma lentigo maligna melanoma and acral lentiginous melanoma the lesion has a period of superficial so-called radial growth during which it increases in size but does not penetrate deeply. It is during this period that the melanoma is most capable of being cured by surgical excision. The fourth type nodular melanoma does not have a recognizable radial growth phase and usually presents as a deeply invasive lesion capable of early metastasis. When tumors begin to penetrate deeply into the skin they are in the so-called vertical growth phase. Melanomas with a radial growth phase are characterized by irregular and sometimes notched borders variation in pigment pattern and variation in color. An increase in size or change in color is noted by the patient in 70 of early lesions. Bleeding ulceration and pain are late signs and are of little help in early recognition. Superficial spreading melanoma is the most frequent variant observed in the white population. Melanomas arising in dysplastic nevi see below are usually of this type. The back is the most common site for melanoma in men. In women the back and the lower leg from knee to ankle are common sites. Nodular melanomas are dark brown-black to blue-black nodules. Lentigo maligna melanoma is usually confined to chronically sun-damaged sun-exposed sites face neck back of hands in older individuals. Acral lentiginous melanoma occurs on the palms soles nail beds and mucous membranes. While this type occurs in whites it is most frequent along with nodular melanoma in blacks and East Asians. Table 83-2 Clinical Features of Malignant Melanoma Type Site Average Age at Diagnosis Years Duration of Known Existence Years Color Lentigo maligna melanoma Sun- exposed surfaces 70 5-20 or longer In flat portions shades of brown and tan particularly malar region of cheek and

• Y học thường thức
• Cancer of the Skin
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu y khoa
• Harrisons Internal Medicine
• BMC Cancer
• Diabetes mellitus
• Non melanoma skin cancer
• Sensitivity analyses
• Cox regression
• Hematopoietic cell transplantation
• Skin cancer
• Skin self examination
• Early detection
• Patient activation
• Breast cancer
• Quality of life
• Radiation irritated skin
• Radiation therapy
• Irradiated skin area
• Psychological impact
• Actinic keratoses
• Methyl aminolevulinate
• Skin field cancerization
• Photodynamic therapy
• Burden of disease
• Years lived with disability
• Public health policies
• Squamous cell carcinoma
• Radiotherapy related skin toxicity
• Head and neck cancer
• Dermatitis related pain
• Acute skin damage
• Hypofractionated radiotherapy
• Postoperative treatment
• Supine immobilization devices
• Intensity modulated radiation therapy
• Skin dose
• Basal cell carcinoma
• P53 gene family
• Epithelial tissue growth
• Breast cancer cells
• Protection motivation theory
• Significant increase
• Quasi experimental interventional
• Demographic information questionnaire
• Medication literacy
• Skin adverse drug reactions
• Non small cell lung cancer
• Targeted therapy
• Metastatic cancer
• Reduce ethnic
• Multivariate models adjusting
• Serum Markers
• Clinical Management
• Malignant Melanoma
• Suncare Products
• Clinical Aspects
• Minocycline application
• Improvement skin disorder
• While epidermal growth factor receptor
• Overall survival
• Pancreatic ductal adenocarcinoma
• Progression free survival
• Skin rash
• Non interventional study
• Molecular genetics
• Gene expression
• Single nucleotide polymorphism
• Transcription factor
• Grainyhead like