tailieunhanh - Báo cáo y học: " Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008 | Zhu et al. Virology Journal 2010 7 300 http content 7 1 300 VIROLOGY JOURNAL RESEARCH Open Access Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008 71 7 1 1 f 1 f 13 1 P s X 1 xz- -1-1 Zhen Zhu Shuangli Zhu Xuebin Guo Jitao Wang Dongyan Wang Dongmei Yan Xiaojuan Tan 1 1 1 X I 1 X 71 1 1 Liuying Tang Hui Zhu Zhaohui Yang Xiaohong Jiang Yixin Ji Yong Zhang Wenbo Xu Abstract Background Large nationwide outbreaks of hand foot and mouth disease HFMD occurred in China from 2008 most of the cases were in children under 5 years. This study aims to identify the situation of natural human enterovirus 71 HEV71 and coxsackievirus A16 CVA16 infections in children before 2008 in China. Results Retrospective seroepidemiologic studies of HEV71 and CVA16 were performed with 900 serum samples collected from children 5 years of age in 2005. The samples were collected from 6 different geographical areas Anhui Guangdong Hunan Xinjiang Yunnan and Heilongjiang provinces in mainland China. Of the 900 samples 288 were positive for HEV71 the total positive rate was and the geometric mean titer GMT was 1 . Guangdong and 1 Xinjiang and 1 and Yunnan and 1 provinces had relatively high rates of infection while Heilongjiang province and 1 had the lowest rate of infection. On the other hand 390 samples were positive for CVA16 the total positive rate was and the GMT was 1 . Anhui and 1 and Hunan and 1 had relatively high rates while Heilongjiang and 1 had the lowest rate. Although there is a geographical difference in HEV71 and CVA16 infections low neutralizing antibody positive rate and titer of both viruses were found in all 6 provinces. Conclusions This report confirmed that HEV71 and CVA16 had wildly circulated in a couple provinces in China before the .