tailieunhanh - Báo cáo y học: " Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection | Loutfy et al. Virology Journal 2010 7 287 http content 7 1 287 VIROLOGY JOURNAL RESEARCH Open Access Presence of Human Herpes Virus 6 HHV6 in pediatric lymphomas impact on clinical course and association with cytomegalovirus infection cmh A I o ipf 1 4K ohl-w. w2 i .WrnocI nl- A olõl3 K onor K l A Io nd dr3 Jdmdn A Loutiy IVIUIIdllled Fawzy IVIUIldlllcU El wakil Manar M Moneer Abstract Background Activation of herpes virus 6 HHV6 has seen in Hodgkin s and non-Hodgkin s Lymphoma HL NHL as a result of lymphoma associated immunosuppression. Multiple studies have suggested an association between both HHV6 and cytomegalovirus CMV for development of CMV disease affecting the pathogenesis of lymphoma. Therefore this study investigated the frequency of HHV6 its impact on clinical manifestations of lymphoma and its possible association with risk for development of CMV infection in pediatric lymphoma patients. Methods Presence of HHV6 DNA and CMV DNA was investigated by PCR assay in both WBC s and plasma samples from 50 patients diagnosed with HL or NHL. CMV antibody titer was also determined in sera obtained from each patient. Twenty apparently healthy siblings were used as a control group. Results In a study group of 50 patients diagnosed with HL or NHL 23 50 46 were found to be positive for herpes virus DNA HHV6 or CMV in WBC s or plasma by PCR assay and this was significantly higher than its presence in the pediatric control group 2 20 10 p . Ten out of these 23 43 were found to have active CMV infection. Fifty six percent of patients with CMV infection were found among NHL cases with B- subtype. The presence of both herpes viruses DNA was significantly associated with more frequent episodes of febrile neutropenia median 3 episodes absolute neutrophil count lymphocytes and low hemoglobin level p . Conclusion The presence of HHV6 can be considered as a predicting indicator of cellular immunosuppression preceding the onset of CMV .