tailieunhanh - Báo cáo y học: "Prevalence of active hepatitis c virus infection in district mansehra pakistan"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prevalence of active hepatitis c virus infection in district mansehra pakistan | Ali et al. Virology Journal 2010 7 334 http content 7 1 334 VIROLOGY JOURNAL RESEARCH Open Access Prevalence of active hepatitis c virus infection in district mansehra Pakistan A m I I A I I 1 2 I_I k I k A L m I 2I 7 A I 13 c p IX I V 4 C I I I r L 7 I I 15 h ỉ I I L KỲ KỲ I I I rxrxr Amjad All Habib Ahmad Ijaz All Sheema Khan uulsnan zaidi MUndmmdQ Idrees Abstract Prevalence of active hepatitis C virus HCV infection in apparently healthy inhabitants of District Mansehra Pakistan was surveyed during September 2009 to May 2010. Subjects of different age and gender groups were analyzed through random blood sampling from people of three areas viz Tehsil Mansehra Tehsil Balakot and Tehsil Oghi. Sum of 400 individuals 300 male and 100 females with age groups from 10 years to 50 and above were included in the study. All the individuals were screened for antibodies against HCV. The positive samples thus screened were subjected to polymerase chain reaction PCR analysis for detection of HCV-RNA. The results showed that of the people of District Mansehra are actively infected with HCV whereas 7 of the population in general has the presence of antibodies against HCV in their blood. It was also concluded that the prevalence of active HCV infection was high 4 in males as compared to females 2 . The prevalence of HCV proportionality increases with the increase in age of the people. Its incidence was highest in the people of the age group of 51 years and above whereas no sign of infection was recorded for the age group of 10-20 years. 1. Background Human hepatitis C is an infectious disease affecting the liver caused by the Hepatitis C Virus HCV . The infection is often asymptomatic but once established it can progress to the fibrosis of liver and ultimately cirrhosis. In some cases those with cirrhosis will go on to develop liver failure and other complications including liver cancer 1 . HCV is the only known member of the Hepaci-virus genus in the .