tailieunhanh - Báo cáo y học: " Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1)"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1) | Taha et al. Virology Journal 2010 7 330 http content 7 1 330 VIROLOGY JOURNAL RESEARCH Open Access Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A H5N1 1 2 3 1 Soad H Taha Mona A Mehrez Mahmoud Z Sitohy Abdel Gawad I Abou Dawood Mahmoud M Abd-El Hamid1 Walid H Kilany2 Abstract Background Avian influenza A H5N1 virus is one of the most important public health concerns worldwide. The antiviral activity of native and esterified whey proteins fractions a- lactalbumin p- lactoglobulin and lactoferrin was evaluated against A chicken Egypt 086Q-NLQP 2008 HPAI H5N1 strain of clade for multiplicity of infection 1 MOI after 72 h of incubation at 37 C in the presence of 5 CO2 using MDCK cell lines. Result Both the native and esterified lactoferrin seem to be the most active antiviral protein among the tested samples followed by p- lactoglobulin. a-Lactalbumin had less antiviral activity even after esterification. Conclusion Esterification of whey proteins fractions especially lactoferrin and p-lactoglobulin enhanced their antiviral activity against H5N1 in a concentration dependent manner. Background Avian influenza A H5N1 virus is one of the most important public health concerns worldwide. It has been detected and identified in South East Asia since 2003. In 2005 the virus was already spread to many countries in Europe Asia and Africa 1 . Later it interrupted international travel and negatively affected the world economy especially tourism. In December 2005 the first case of H5N1 in Egypt was detected in a migrating bird in Damietta Governorate. In mid-February 2006 H5N1 infection was reported in Egypt among domestic poultry in more than 15 governorates resulting in severe losses for the poultry industry. In March 2006 the first human case of H5N1 in Egypt was detected 2 . Egypt had the highest number of confirmed human avian influenza cases outside Asia. As of 4 March 2010 104 human cases including 30 .