tailieunhanh - báo cáo khoa học:" Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea | Lee et al. Health and Quality of Life Outcomes 2010 8 101 http content 8 1 101 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea 12 1 1 11 1 Ji In Lee Soo Hyun Kim Alice H Tan Hee Kyung Kim Hye Won Jang Kyu Yeon Hur Jae Hyeon Kim Kwang-Won Kim 1 Jae Hoon Chung1 Sun Wook Kim1 Abstract Background Concern regarding the health-related quality of life HRQOL of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-free survivors of differentiated thyroid carcinoma DTC and to evaluate the important determinants of HRQOL. Methods This was a cross-sectional study in which we interviewed consecutive disease-free survivors of DTC. Three different validated questionnaires EORTC QLQ-C30 for various functional domains the brief fatigue inventory BFI and the hospital anxiety and depression scale HADS were used. Data from a large population based survey of 1 000 people were used as a control. Results The response rate for the questionnaires was 316 401 . Disease-free survivors of DTC showed a decreased HRQOL in all five functional domains physical role cognitive emotional and social on the EORTC QLQ-C30 compared with controls P . BFI and HADS-anxiety scores also showed greater distress in disease-free survivors of DTC than in controls P . A multiple regression analysis for the determinants of HRQOL showed that the HADS-anxiety HADS-depression and BFI scores were the most significant components of decreased HRQOL. Conclusions Although disease-free survivors of DTC are expected to have disease-specific survival comparable to the general population they experience a significantly decreased HRQOL. Anxiety depression and fatigue were the major determinants of the decreased HRQOL.