tailieunhanh - Báo cáo y học: "Dynamic correlation between CTL response and viral load in primary human immunodeficiency virus-1 infected Koreans"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dynamic correlation between CTL response and viral load in primary human immunodeficiency virus-1 infected Koreans | Kim et al. Virology Journal 2010 7 239 http content 7 1 239 VIROLOGY JOURNAL RESEARCH Open Access Dynamic correlation between CTL response and viral load in primary human immunodeficiency virus-1 infected Koreans Gab Jung Kim Hak Sung Lee Kee-Jong Hong Sung Soon Kim Abstract Background HIV-1 specific cytotoxic T lymphocytes CTLs have an important role as antiviral effector cells for controlling HIV-1 infection. Methods To investigate CTL response during the early stage of HIV infection we measured immunity-related factors including CD4 T cell counts CD8 T cell counts HIV-1 RNA viral loads and IFN-y secretion according to CTL response in 78 selected primary HIV-1-infected Koreans. Results The CTL response was strongly induced by HIV-1 specific Gag and Nef peptides p compared with induction by Tat or Env peptides. These results suggest that the major antiviral factors inducing strong HIV-specific CTL responses are associated with the Gag and Nef viral regions in primary HIV-1 infected Koreans. The relationship between viral load and CTL response showed varying correlations with time following HIV infection. CTL response was inversely correlated with viral loads at preseroconversion stage I r to and changed to a positive correlation at the preseroconversion stage II r to . Finally it changed to an inverse correlation again after seroconversion until a viral set point was established on serological profiling r to . Conclusions These findings demonstrate a dynamic correlation between viral load and subsequent CTL responses during early HIV infection. Background Human immunodeficiency virus type 1 HIV-1 specific CD8 T cells play a key role in the control of viral replication during HIV-1 infection. The cytotoxic T lymphocyte CTL response is mainly measured at the early stage of infection and its appearance coincides with a rapid fall in plasma viremia during the early stage of infection with HIV-1 1 . One of