tailieunhanh - báo cáo khoa học:" Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders | Konig et al. Health and Quality of Life Outcomes 2010 8 47 http content 8 1 47 I HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders Hans-Helmut Kõnig 1 2 Anja Born3 Oliver Gunther2 Herbert Matschinger4 Sven Heinrich1 2 Steffi G Riedel-Heller5 Matthias C Angermeyer6 and Christiane Roick2 Abstract Background The EQ-5D is a generic questionnaire which generates a health profile as well as index scores for health-related quality of life that may be used in cost-utility analysis. Aims of the study To examine validity and responsiveness of the EQ-5D in patients with anxiety disorders. Methods 389 patients with anxiety disorders completed the EQ-5D at baseline and 6-month follow-up. Subjective measures of quality of life WHOQOL-BREF and psychopathology BAI BDI-II BSQ ACQ MI were used for comparison. Validity was analyzed by assessing associations between EQ-5D scores and related other scores. Responsiveness was analyzed by calculating effect sizes of differences in scores between baseline and follow-up for 3 groups indicating more constant or less anxiety. Meaningful difference scores for shifting to less or more anxiety were derived by means of regression analysis. Results of respondents reported problems in at least one of the EQ-5D dimension at baseline the mean EQ VAS score was . The EQ-5D dimension most consistently associated with the measures used for comparison was anxiety depression1. EQ VAS and EQ-5D index scores were highly correlated r with scores of the WHOQOL-BREF dimensions physical mental and overall as well as BAI and BDI-II. The EQ-5D index tended to be the most responsive score. Standardized meaningful difference scores were not significantly different between EQ VAS EQ-5D index and measures used for comparison. Conclusions The EQ-5D seems to be reasonably valid and moderately responsive in patients with .