tailieunhanh - báo cáo khoa học:" Using qualitative methods to inform the trade-off between content validity and consistency in utility assessment: the example of type 2 diabetes and Alzheimer’s Disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Using qualitative methods to inform the trade-off between content validity and consistency in utility assessment: the example of type 2 diabetes and Alzheimer’s Disease | Mcgrath et al. Health and Quality of Life Outcomes 2010 8 23 http content 8 1 23 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Using qualitative methods to inform the trade-off between content validity and consistency in utility assessment the example of type 2 diabetes and Alzheimer s Disease Clare Mcgrath1 Diana Rofail 2 Elizabeth Gargon2t Linda Abetz2t Abstract Background Key stakeholders regard generic utility instruments as suitable tools to inform health technology assessment decision-making regarding allocation of resources across competing interventions. These instruments require a descriptor a valuation and a perspective of the economic evaluation. There are various approaches that can be taken for each of these offering a potential lack of consistency between instruments a basic requirement for comparisons across diseases . The reference method has been proposed as a way to address the limitations of the Quality-Adjusted Life Year QALY . However the degree to which generic measures can assess patients specific experiences with their disease would remain unresolved. This has been neglected in the discussions on methods development and its impact on the QALY values obtained and resulting cost per QALY estimate underestimated. This study explored the content of utility instruments relevant to type 2 diabetes and Alzheimer s disease AD as examples and the role of qualitative research in informing the trade-off between content coverage and consistency. Method A literature review was performed to identify qualitative and quantitative studies regarding patients experiences with type 2 diabetes or AD and associated treatments. Conceptual models for each indication were developed. Generic- and disease-specific instruments were mapped to the conceptual models. Results Findings showed that published descriptions of relevant concepts important to patients with type 2 diabetes or AD are available for consideration in deciding on the most .