tailieunhanh - CHRONIC LYMPHOCYTIC LEUKEMIA

Chronic lymphocytic leukemia (CLL) follows an extremely variable course with survival ranging from months to decades. Recently, there has been major progress in the identification of molecular and cellular markers that may predict the tendency for disease progression in CLL patients. In particular, the mutational profile of Ig genes and some cytogenetic abnormalities have been found to be important predictors of prognosis in CLL. However, this progress has raised new questions about the biology, prognosis and management of the disease, some of which are addressed here. . | CHRONIC LYMPHOCYTIC LEUKEMIA Edited by Pablo Oppezzo Chronic Lymphocytic Leukemia Edited by Pablo Oppezzo Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Marko Rebrovic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February 2012 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Chronic Lymphocytic Leukemia Edited by Pablo Oppezzo p. cm. 978-953-307-881-6 INTECH open science I open minds free online editions of InTech Books and Journals can be found at .