tailieunhanh - Chapter 061. Disorders of Granulocytes and Monocytes (Part 3)

Pelger-Hüet anomaly. In this benign disorder, the majority of granulocytes are bilobed. The nucleus frequently has a spectacle-like, or "pince-nez," configuration. In severe acute bacterial infection, prominent neutrophil cytoplasmic granules, called toxic granulations, are occasionally seen. Toxic granulations are immature or abnormally staining azurophil granules. Cytoplasmic inclusions, also called Döhle bodies (Fig. 61-3), can be seen during infection and are fragments of ribosome-rich endoplasmic reticulum. Large neutrophil vacuoles are often present in acute bacterial infection and probably represent pinocytosed (internalized) membrane. Neutrophils are heterogeneous in function. Monoclonal antibodies have been developed that recognize only a subset of mature neutrophils. The meaning. | Chapter 061. Disorders of Granulocytes and Monocytes Part 3 Pelger-Hüet anomaly. In this benign disorder the majority of granulocytes are bilobed. The nucleus frequently has a spectacle-like or pince-nez configuration. In severe acute bacterial infection prominent neutrophil cytoplasmic granules called toxic granulations are occasionally seen. Toxic granulations are immature or abnormally staining azurophil granules. Cytoplasmic inclusions also called Döhle bodies Fig. 61-3 can be seen during infection and are fragments of ribosome-rich endoplasmic reticulum. Large neutrophil vacuoles are often present in acute bacterial infection and probably represent pinocytosed internalized membrane. Neutrophils are heterogeneous in function. Monoclonal antibodies have been developed that recognize only a subset of mature neutrophils. The meaning of neutrophilheterogeneity is not known. The morphology of eosinophils and basophils is shown in Fig. 61-6. Figure 61-6 Sourc F uci as. K sptr DL. Bnunwiid E. Hauler 5Lr Longo C l Jimtion JL- Loicdco Ji An MÛtejr 0 tedero 17th Edition http7 sim di ein .com ------------------------------------------------------------------------------------. Copyright Ö Tho Mc r w-H i Companies Inc All tight 1 éíeruéd. Normal eosinophil and basophil. The eosinophil contains large bright orange granules and usually a bilobed nucleus. The basophil contains large purpleblack granules that fill the cell and obscure the nucleus Marrow Release and Circulating Compartments Specific signals including IL-1 tumor necrosis factor a TNF-a the CSFs complement fragments and chemokines mobilize leukocytes from the bone marrow and deliver them to the blood in an unstimulated state. Under normal conditions 90 of the neutrophil pool is in the bone marrow 2-3 in the circulation and the remainder in the tissues Fig. 61-7 . Figure 61-7 Citculeiing pool Tissue Marinated pool Sour F uo AS. K p r Dl. Sr unw ld E. H u r SL longo DL. JL. Loicolso J Mawiroo f .