tailieunhanh - THE MANAGEMENT OF SICKLE CELL DISEASEN

RF and RHD remain significant causes of cardiovascular diseases in the world today. Despite a documented decrease in the incidence of acute RF and a similar documented decrease in the prevalence of RHD in industrialized countries during the past five decades, these non-suppurative cardiovascular sequel of group A streptococcal pharyngitis remain medical and public health problems in both indus- trialized and industrializing countries even at the beginning of the 21st century. The most devastating effects are on children and young adults in their most productive years | Division ofBlood Diseases and Resources Ma n a g e m e n t O F Si c k l e Ce l l Di s e a s e N ATIONAL INSTITUTES OF HEALTH N ATIONAL HEART LUNG and blood institute The Management OF Sickle Cell Disease National Institutes OF Health National Heart Lung and Blood Institute Division of Blood Diseases and Resources NIH Publication No. 02-2117 ORIGINALLY Printed 1984 Previously Revised 1989 1995 Reprinted June 1999 Revised June 2002 Fourth edition

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