tailieunhanh - Báo cáo y học: " 2-year survival of patients undergoing mild hypothermia treatment after ventricular fibrillation cardiac arrest is significantly improved compared to historical controls"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: 2-year survival of patients undergoing mild hypothermia treatment after ventricular fibrillation cardiac arrest is significantly improved compared to historical controls | Storm et al. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2010 18 2 http content 18 1 2 SCANDINAVIAN JOURNAL OF t emergency medicine ORIGINAL RESEARCH Open Access 2-year survival of patients undergoing mild hypothermia treatment after ventricular fibrillation cardiac arrest is significantly improved compared to historical controls Christian Storm Jens Nee Anne Krueger Joerg C Schefold Dietrich Hasper Abstract Background Therapeutic hypothermia has been proven to be effective in improving neurological outcome in patients after cardiac arrest due to ventricular fibrillation VF . Data concerning the effect of hypothermia treatment on long-term survival however is limited. Materials and methods Clinical and outcome data of 107 consecutive patients undergoing therapeutic hypothermia after cardiac arrest due to VF were compared with 98 historical controls. Neurological outcome was assessed at ICU discharge according to the Pittsburgh cerebral performance category CPC . A Kaplan-Meier analysis of follow-up data concerning mortality after 24 months as well as a Cox-regression to adjust for confounders were calculated. Results Neurological outcome significantly improved after mild hypothermia treatment hypothermia group CPC 1-2 control group CPC 1-2 p . In Kaplan-Meier survival analysis hypothermia treatment was also associated with significantly improved 2-year probability for survival hypothermia 55 vs. control 34 p . Cox-regression analysis revealed hypothermia treatment p and age p as independent predictors of 24-month survival. Conclusions Our study demonstrates that the early survival benefit seen with therapeutic hypothermia persists after two years. This strongly supports adherence to current recommendations regarding postresuscitation care for all patients after cardiac arrest due to VF and maybe other rhythms as well. Introduction Patients surviving cardiac arrest still have a poor prognosis .