tailieunhanh - báo cáo khoa học:" Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer : a randomised, controlled clinical trial"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer : a randomised, controlled clinical trial | Head Face Medicine BioMed Central Research Circulating Immune Complexes and trace elements Copper Iron and Selenium as markers in oral precancer and cancer a randomised controlled clinical trial Sunali S Khanna 1 and Freny R Karjodkar2 Open Access Address Department of Oral Medicine and Radiology Nair Hospital Dental College Mumbai India and 2Department of Oral Medicine and Radiology Nair Hospital Dental College Mumbai India Email Sunali S Khanna - sunali3011@ Freny R Karjodkar - fkarjodkar@ Corresponding author Published 16 October 2006 Received 04 March 2006 Head Face Medicine 2006 2 33 doi l746-l60X-2-33 Accepted 16 October 2006 This article is available from http content 2 l 33 2006 Khanna and Karjodkar licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Aim To evaluate the levels of circulating immune complexes trace elements copper iron and selenium in serum of patients with oral submucous fibrosis OSMF oral leukoplakia L and oral squamous cell carcinoma SCC analyze the alteration and identify the best predictors amongst these parameters for disease occurrence and progression. Methods Circulating immune complexes CIC were estimated using Polyethylene Glycol 6000 PEG serum precipitation. Serum estimation of copper Cu Iron Fe and selenium Se was done using the Oxalyl Dihydrazide method Colorimetric Dipyridyl method and the Differential Pulse Cathodic Stripping Voltametry respectively. Results The data analysis revealed increased circulating immune complex levels in the precancer and cancer patients. Serum copper levels showed gradual increase from precancer to cancer .