tailieunhanh - Báo cáo y học: " In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch | Hanke et al. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2011 19 12 http content 19 1 12 SCANDINAVIAN JOURNAL OF St emergency medicine ORIGINAL RESEARCH Open Access In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch AlovsmHor Ạ I Icml cJftQnhoniQ i l Cf hdcir2 I larKarf Qr L irsr L d3 PoliV Plrsrid O1 1 1 IC c rsrlinnor4 1 1 IC y nnar 5 Aiexdndei A Hdiikc Stephdnie Mdschiei neibeit Scuucin reiix riuiicke Kidus GUiiingei Kidus Zdngei Peter Kienbdum2 Abstract Background Hypertonic sdiine hydioxyethyi stdich HH hds been recommended foi fiist iine tiedtment of hemorthdgic shock. Its effects on codguidtion die unciedi. We studied in vitio effects of HH diiution on whoie biood codguidtion dnd pidteiet function. Fuitheimoie hypertonic sdiine 6 hydioxyethyistdich ds ingredients of HH dnd sdiine soiution ds contioi weie tested in compdidbie diiutions to estimdte specific component effects of HH on codguidtion. Methods The study wds designed ds expeiimentdi non-idndomized compdidtive in vitio study. Foiiowing institutiondi review bodid dppiovdi dnd infoimed consent biood sdmpies weie tdken fiom 10 hedithy voiunteeis dnd diiuted in vitio with eithei HH HypeiHdes Fiesenius Kdbi Geimdny hypertonic sdiine HT NdCi hydioxyethyistdich HS HAES6 Fiesenius Kdbi Geimdny oi NdCi ISO in d proportion of 5 10 20 dnd 40 . Codguidtion wds studied in whoie biood by iotdtion thiombeidstometiy ROTEM dftei thiombopidstin dctivdtion without ExTEM dnd with inhibition of thiombocyte function by cytochdidsin D FibTEM the idttei wds peifoimed to deteimine fibiin poiymeiisdtion dione. Vdiues die expressed ds mdximdi ciot fiimness MCF mm dnd ciotting time CT s . Pidteiet dggiegdtion wds deteimined by impeddnce dggiegiometiy Muitipidte dftei dctivdtion with thiombin ieceptoi-dctivdting peptide 6 TRAP dnd qudntified by the died undei the dggiegdtion cuive AUC dggiegdtion units AU min . .