tailieunhanh - Báo cáo y học: " Prehospital randomised assessment of a mechanical compression device in cardiac arrest (PaRAMeDIC) trial protocol"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Prehospital randomised assessment of a mechanical compression device in cardiac arrest (PaRAMeDIC) trial protocol | Perkins et al. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2010 18 58 http content 18 1 58 SCANDINAVIAN JOURNAL OF 8 emergency medicine STUDY PROTOCOL Open Access Prehospital randomised assessment of a mechanical compression device in cardiac arrest PaRAMeDIC trial protocol 1 2 3 4 11 Gavin D Perkins Malcolm Woollard Matthew W Cooke Charles Deakin Jessica Horton Ranjit Lall Sarah E Lamb1 Chris McCabe5 Tom Quinn6 Anne Slowther7 Simon Gates1 PARAMEDIC trial collaborators1 Abstract Background Survival after out-of-hospital cardiac arrest is closely linked to the quality of CPR but in real life resuscitation during prehospital care and ambulance transport is often suboptimal. Mechanical chest compression devices deliver consistent chest compressions are not prone to fatigue and could potentially overcome some of the limitations of manual chest compression. However there is no high-quality evidence that they improve clinical outcomes or that they are cost effective. The Prehospital Randomised Assessment of a Mechanical Compression Device In Cardiac Arrest PARAMEDIC trial is a pragmatic cluster randomised study of the LUCAS-2 device in adult patients with non-traumatic out-of-hospital cardiac arrest. Methods design The primary objective of this trial is to evaluate the effect of chest compression using LUCAS-2 on mortality at 30 days post out-of-hospital cardiac arrest compared with manual chest compression. Secondary objectives of the study are to evaluate the effects of LUCAS-2 on survival to 12 months cognitive and quality of life outcomes and cost-effectiveness. Methods Ambulance service vehicles will be randomised to either manual compression control or LUCAS arms. Adult patients in out-of-hospital cardiac arrest attended by a trial vehicle will be eligible for inclusion. Patients with traumatic cardiac arrest or who are pregnant will be excluded. The trial will recruit approximately 4000 patients from England Wales and .