tailieunhanh - Báo cáo y học: "The quantitation of buffering action I. A formal & general approach"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The quantitation of buffering action I. A formal & general approach | Theoretical Biology and Medical Modelling BioMed Central Research Open Access The quantitation of buffering action I. A formal general approach Bernhard M Schmitt Address Department of Anatomy University of Wurzburg 97070 Wurzburg Germany Email Bernhard M Schmitt - Corresponding author Published 15 March 2005 Received 26 August 2004 Theoretical Biology and Medical Modelling 2005 2 8 doi 1742-4682-2-8 Accepted 15 March 2005 This article is available from http content 2 1 8 2005 Schmitt licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Although buffering as a homeostatic mechanism is a universal phenomenon the quantitation of buffering action remains controversial and problematic. Major shortcomings are lack of a buffering strength unit for some buffering phenomena multiple and mutually incommensurable units for others and lack of a genuine ratio scale for buffering strength. Here I present a concept of buffering that overcomes these shortcomings. Theory Briefly when for instance some free H ions are added to a solution . in the form of strong acid buffering is said to be present when not all H ions remain free . bound to H2O but some become bound . bound to molecules other than H2O . The greater the number of H ions that become bound in this process the greater the buffering action. This number can be expressed in two ways With respect to the number of total free ions added as buffering coefficient b defined in differential form as b d bound d total . This measure expresses buffering action from nil to complete by a dimensionless number between 0 and 1 analogous to probabilites. 2 With respect to the complementary number of added ions .

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