tailieunhanh - Báo cáo y học: "Free radical theory of autoimmunity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Free radical theory of autoimmunity | Theoretical Biology and Medical Modelling Research Free radical theory of autoimmunity Subburaj Kannan BioMed Central Open Access Address DNA Repair Drug Resistance Group Departments of Microbiology and Immunology School of Medicine University of Texas Medical Branch Galveston Texas 77555-0609 USA Email SubburajKannan - skannan22@ Corresponding author Published 07 June 2006 Received 19 December 2005 Theoretical Biology and Medical Modelling 2006 3 22 doi 1742-4682-3-22 Accepted 07 June 2006 This article is available from http content 3 1 22 2006 Kannan licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Despite great advances in clinical oncology the molecular mechanisms underlying the failure of chemotherapeutic intervention in treating lymphoproliferative and related disorders are not well understood. Hypothesis A hypothetical scheme to explain the damage induced by chemotherapy and associated chronic oxidative stress is proposed on the basis of published literature experimental data and anecdotal observations. Brief accounts of multidrug resistance lymphoid malignancy the cellular and molecular basis of autoimmunity and chronic oxidative stress are assembled to form a basis for the hypothesis and to indicate the likelihood that it is valid in vivo. Conclusion The argument set forward in this article suggests a possible mechanism for the development of autoimmunity. According to this view the various sorts of damage induced by chemotherapy have a role in the pattern of drug resistance which is associated with the initiation of autoimmunity. Background review of the literature