tailieunhanh - Báo cáo y học: " Fibrinogen metabolic responses to trauma Wenjun Zhou Martini"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Fibrinogen metabolic responses to trauma Wenjun Zhou Martini | Scandinavian Journal of Trauma Resuscitation and Emergency Medicine BioMed Central Review Fibrinogen metabolic responses to trauma Wenjun Zhou Martini Address . Army Institute of Surgical Research Ft. Sam Houston TX 78234 USA Email Wenjun Zhou Martini - Open Access Published 13 January 2009 Received 22 November 2008 __. r-T nù. --. mno - .- I lo mrv T . I Accepted 13 January 2009 Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2009 17 2 doi l 757-7241-172 This article is available from http content l7 l 2 2009 Martini licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Coagulation complications are significant contributors to morbidity and mortality in trauma patients. Although the lethal triad of hypothermia acidosis and coagulopathy has been recognized for over a decade the underlying mechanisms related to the development of coagulopathy remain unclear. Recent data suggest that decreased fibrinogen levels contribute to the development of coagulation disorders. Thus regulation of fibrinogen availability not fully understood at present may play an important role in survival of trauma patients. This review summarizes the recent findings of the studies that have explored mechanisms related to changes in fibrinogen availability following trauma-related events. Trauma alters fibrinogen metabolism in a variety of ways hemorrhage - accelerated fibrinogen breakdown hypothermia - inhibited fibrinogen synthesis and acidosis - accelerated fibrinogen breakdown. However hemorrhage hypothermia andcidosis all result in a consistent outcome of fibrinogen availability deficit supporting the notion of fibrinogen .