tailieunhanh - Báo cáo y học: "Investigation of hydrophobic moment and hydrophobicity properties for transmembrane α-helices"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Investigation of hydrophobic moment and hydrophobicity properties for transmembrane α-helices | Theoretical Biology and Medical Modelling BioMed Central Research Investigation of hydrophobic moment and hydrophobicity properties for transmembrane a-helices James Wallace1 Onkabetse A Daman1 Frederick Harris2 and David A Phoenix 3 Open Access Address Department of Physics Astronomy and Mathematics University of Central Lancashire Preston PR1 2HE UK 2Department of Forensic and Investigative Science University of Central Lancashire Preston PR1 2HE UK and 3The Dean s Office Faculty of Science University of Central Lancashire Preston PR1 2HE UK Email James Wallace - daphoenix@ Onkabetse A Daman - daphoenix@ Frederick Harris - fharris1@ David A Phoenix - daphoenix@ Corresponding author Published 16 August 2004 Received II August 2004 Theoretical Biology and Medical Modelling 2004 1 5 doi 1742-4682-1-5 Accepted 16 August 2004 This article is available from http content 1 1 5 2004 Wallace et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Integral membrane proteins are the primary targets of novel drugs but are largely without solved structures. As a consequence hydrophobic moment plot methodology is often used to identify putative transmembrane a-helices of integral membrane proteins based on their local maximum mean hydrophobic moment ậH and the corresponding mean hydrophobicity H . To calculate these properties the methodology identifies an optimal eleven residue window L 11 assuming an amino acid angular frequency 0 fixed at 100 . Using a data set of 403 transmembrane a-helix forming sequences the relationship between yH and H and the effect of varying of L and or 0on this relationship was investigated. Confidence intervals for correlations .