tailieunhanh - Báo cáo y học: " Blood transfusion in the critically ill: does storage age matter?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Blood transfusion in the critically ill: does storage age matter? | Scandinavian Journal of Trauma Resuscitation and Emergency Medicine BioMed Central Open Access Review Blood transfusion in the critically ill does storage age matter Marianne J Vandromme Gerald McGwin Jr and Jordan A Weinberg Address Department of Surgery Center for Injury Sciences University of Alabama at Birmingham Birmingham AL USA Email Marianne J Vandromme - Gerald McGwin - Jordan AWeinberg - jweinberg@ Corresponding author Published 13 August 2009 Received 1 June 2009 Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2009 17 35 doi 186 1757-7241-17-35 Accepted 13 August 2009 This article is available from http content 17 1 35 2009 Vandromme et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Morphologic and biochemical changes occur during red cell storage prior to product expiry and these changes may hinder erythrocyte viability and function following transfusion. Despite a relatively large body of literature detailing the metabolic and structural deterioration that occurs during red cell storage evidence for a significant detrimental clinical effect related to the transfusion of older blood is relatively less conclusive limited primarily to observations in retrospective studies. Nonetheless the implication that the transfusion of old but not outdated blood may have negative clinical consequences demands attention. In this report the current understanding of the biochemical and structural changes that occur during storage known collectively as the storage lesion is described and the clinical evidence concerning the detrimental consequences associated with the transfusion of relatively older red cells is .