tailieunhanh - Dioxin and Related Compounds

Explore dioxins and dioxin-like compounds. • Summarize the structural similarities of cogeners of dioxins and furans. • Understand Toxicity Equivalency Factors (TEF) and Toxicity Equivalents (TEQ) for dioxins and related compounds. • Summarize the known processes and toxicological endpoints of dioxin exposure. | Dioxin and Related Compounds Principles of Environmental Toxicology Instructor Gregory Möller . University of Idaho Principles of Environmental Toxicology Learning Objectives Explore dioxins and dioxin-like compounds. Summarize the structural similarities of cogeners of dioxins and furans. Understand Toxicity Equivalency Factors TEF and Toxicity Equivalents TEQ for dioxins and related compounds. Summarize the known processes and toxicological endpoints of dioxin exposure. 2 Principles of Environmental Toxicology Learning Objectives Describe the controversy and data needs concerning low-level dioxin exposure. Describe the observed effects and major findings of animal studies with dioxin. Summarize the environmental and food sources of dioxins. Summarize the known human risk estimations for dioxins. Summarize the regulatory control approaches for dioxin release. 3 Principles of Environmental Toxicology The Organochlorine Legacy Halogenated organics have been used as synthetic pesticides and industrial compounds for since before WWII - stable Chlorinated compounds can be formed by combustion and natural processes in the presence of chlorine dioxins Often non-polar and lipophillic they have the ability to be sequestered in fat tissue Can bioaccumulate up the food chain Can circulate in the liposphere Principles of Environmental Toxicology Organochlorine Compounds Often related to immune dysfunction neurological effects cancer endocrine disruption and other toxicological endpoints Chlorinated compounds all around us Often the effects of low-level exposure are sub-clinical and biomolecular and this complicates the risk assessment for low-level exposure 5 Principles of Environmental Toxicology 2003 NAS Institute of Medicine Analysis Dioxins and Dioxin-like Compounds in the Food Supply 2003 - http 6 1 Principles of Environmental Toxicology Dioxins NAS IOM Widespread low-level contaminants in animal feeds and the human food supply. .