tailieunhanh - Báo cáo y học: " Effect of transverse gap-junction channels on transverse propagation in an enlarged PSpice model of cardiac muscle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of transverse gap-junction channels on transverse propagation in an enlarged PSpice model of cardiac muscle | BioMed Central Theoretical Biology and Medical Modelling Research Open Access Effect of transverse gap-junction channels on transverse propagation in an enlarged PSpice model of cardiac muscle Lakshminarayanan Ramasamy1 and Nicholas Sperelakis 2 Address 1Dept. of Electrical Computer Engineering and Computer Science University of Cincinnati College of Engineering Cincinnati OH 45219 USA and 2Dept. of Molecular Cellular Physiology University of Cincinnati College of Medicine Cincinnati OH 45267-0576 USA Email Lakshminarayanan Ramasamy- laksnarayana@ Nicholas Sperelakis - spereln@ Corresponding author Published 16 March 2006 Received 13 February 2006 Theoretical Biology and Medical Modelling2006 3 14 doi l742-4682-3-l4 Accepted 16 March 2006 This article is available from http content 3 l 14 2006Ramasamy and Sperelakis licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In previous PSpice modeling studies of simulated action potentials APs in parallel chains of cardiac muscle it was found that transverse propagation could occur between adjacent chains in the absence of gap-junction gj channels presumably by the electric field EF generated in the narrow interstitial space between the chains. Transverse propagation was sometimes erratic the more distal chains firing out of order. Methods In the present study the propagation of complete APs was studied in a 2-dimensional network of l00 cardiac muscle cells l0 X l0 model . Various numbers of gj-channels assumed to be l00 pS each were inserted across the junctions between the longitudinal cells of each chain and between adjacent chains only at the end cells of each chain . The shunt resistance produced by the gj-channels