tailieunhanh - Báo cáo y học: " Number of active transcription factor binding sites is essential for the Hes7 oscillator"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Number of active transcription factor binding sites is essential for the Hes7 oscillator | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Number of active transcription factor binding sites is essential for the Hes7 oscillator Stefan Zeiser 1 H Volkmar Liebscher2 Hendrik Tiedemann3 Isabel Rubio- Aliaga3 Gerhard KH Przemeck3 Martin Hrabé de Angelis3 and Gerhard Winkler1 Address 1Institute of Biomathematics and Biometry GSF-National Research Centre for Environment and Health Ingolstadter Landstrape 1 D85764 Neuherberg Germany 2Department of Mathematics and Computer Science Ernst-Moritz-Arndt-Universitat Greifswald Jahnstrape 15a D17487 Greifswald Germany and institute of Experimental Genetics GSF-National Research Centre for Environment and Health Ingolstadter Landstrape 1 D-85764 Neuherberg Germany Email Stefan Zeiser - zeiser@ H Volkmar Liebscher - Hendrik Tiedemann - tiedemann@ Isabel Rubio-Aliaga - Gerhard KH Przemeck - przemeck@ Martin Hrabé de Angelis - hrabe@ Gerhard Winkler - gwinkler@ Corresponding author Published 23 February 2006 Received 08 February 2006 Theoretical Biology and Medical Modelling 2006 3 11 doi 1742-4682-3-11 Accepted 23 February 2006 This article is available from http content 3 1 1 1 2006 Zeiser et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It is commonly accepted that embryonic segmentation of vertebrates is regulated by a segmentation clock which is induced by the cycling genes Hesl and Hes7. Their products form dimers that bind to the regulatory regions and thereby repress the transcription of their own encoding genes. An increase of the half-life of Hes7 protein causes irregular somite formation. This was shown in .