tailieunhanh - Báo cáo y học: " Computer simulation analysis of normal and abnormal development of the mammalian diaphragm"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Computer simulation analysis of normal and abnormal development of the mammalian diaphragm | Theoretical Biology and Medical Modelling Research Computer simulation analysis of normal and abnormal development of the mammalian diaphragm Jason C Fisher1 and Lawrence Bodenstein 1 2 BioMed Central Open Access Address 1Division of Pediatric Surgery Morgan Stanley Children s Hospital of New York-Presbyterian and Department of Surgery College of Physicians and Surgeons Columbia University 3959 Broadway 216B New York NY 10032 USA and 2Olana Technologies Inc. 5424 Arlington Avenue H51 Bronx NY 10471 USA Email Jason C Fisher - jcf2102@ Lawrence Bodenstein - lb2126@ Corresponding author Published 17 February 2006 Received 23 September 2005 Theoretical Biology and Medical Modelling2006 3 9 doi 1742-4682-3-9 Accepted I7 February 2006 This article is available from http content 3 1 9 2006Fisher and Bodenstein licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Congenital diaphragmatic hernia CDH is a birth defect with significant morbidity and mortality. Knowledge of diaphragm morphogenesis and the aberrations leading to CDH is limited. Although classical embryologists described the diaphragm as arising from the septum transversum pleuroperitoneal folds PPF esophageal mesentery and body wall animal studies suggest that the PPF is the major if not sole contributor to the muscular diaphragm. Recently a posterior defect in the PPF has been identified when the teratogen nitrofen is used to induce CDH in fetal rodents. We describe use of a cell-based computer modeling system Nudge to study diaphragm morphogenesis. Methods and results Key diaphragmatic structures were digitized from transverse serial sections of paraffin-embedded mouse embryos at embryonic days and .

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