tailieunhanh - Báo cáo y học: " Managing a locally advanced malignant thymoma complicated by nephrotic syndrome: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Managing a locally advanced malignant thymoma complicated by nephrotic syndrome: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Managing a locally advanced malignant thymoma complicated by nephrotic syndrome a case report Daren CY Teoh and Ahmed El-Modir Address Cancer Centre Queen Elizabeth Hospital Birmingham B15 2TH UK Email Daren CYTeoh - dcy_teoh@ Ahmed El-Modir-elmodir@ Corresponding author Published 19 March 2008 Received 12 September 2007 Journal of Medical Case Reports 2008 2 89 doi 1752-1947-2-89 Accepted 19 March 2008 This article is available from http content 2 l 89 2008 Teoh and El-Modir licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The management of locally advanced inoperable malignant thymoma is difficult as there are no large randomized clinical trial data to guide treatment. However various case series have shown that malignant thymoma is often a chemosensitive disease. Cisplatin-based chemotherapy has been the gold-standard in the management of these patients. However when thymic cancers are complicated by paraneoplastic syndromes that damage kidney and neurological function cisplatin use is often contraindicated. Case presentation We report a case of a 37 year old man with locally advanced malignant thymoma complicated by significant nephrotic syndrome and renal impairment. He responded to a novel combination of carboplatin epirubicin and cyclophosphamide chemotherapy used as first line therapy. Conclusion The treatment with chemotherapy of locally advanced malignant thymoma complicated by nephrotic syndrome and renal impairment is difficult due to the increase of toxicity. In this case a novel chemotherapy combination with lesser toxicity was used successfully. In addition this